Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
Seven experimental animals were intradermally injected with a 0.1% concentration and epidermally exposed to a 10% concentration, while 3 control animals were similarly treated, but with the vehicle only.
Two weeks after the epidermal application all animals were challenged with a 2% test substance concentration and the vehicle. The challence reactions were assessed 24 and 48 hours after bandage removal.
No evidence was obtained that DAB (1,4 Diaminobutane) caused skin hypersensitivity in the guinea pig. This result leads to a sensitisation rate of 0%, indicating that DAB (1,4 Diaminobutane) need not to be regarded as a potential skin sensitiser.

Justification for classification or non-classification