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EC number: 203-782-3
CAS number: 110-60-1
• 0.0 ml/kg (control group): no abnormalities.
• 0.35 ml/kg (=307 mg/kg): slight to severe erythema, slight edema and
• 0.7 ml/kg (=614 mg/kg): moderate to severe erythema, moderate to
severe edema and extensive hemorrhages.
• 1.4 ml/kg (=1228 mg/kg): severe erythema, moderate to severe edema,
extensive hemorrhages, apathy, sialorrhoea, dyspnea, dark discoloration
of irises, paresis and/or paralysis.
Mortality amounted to 25% at 0.35 and 0.7 ml/kg bw, and to 100% at 1.4
Growth was slightly disturbed at 0.35 and 0.7 ml/kg bw.
Food and water intake and haematology were not affected by 1,4
Microscopic examination at autopsy revealed treatment related changes in
the skin at 0.35 and 0.7 ml/kg bw.
There were no distinct differences in reactions either between rabbits
treated on the intact or abraded skin, or between male and female
DAB: LD50(rabbit, dermal):
0.7-1.4 ml/kg body weight (=614 -1228 mg/kg bw); extrapolated: 825 mg/kg
Classification DSD (400< LD50
<2000 mg/kg): Xn Harmful, R22 Harmful in contact with skin.
CLP (200 -1000 mg/kg): GHS06 Toxic (cat.3) H311 Toxic in
contact with skin
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