Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-782-3
CAS number: 110-60-1
• 0.0 ml/kg (control group): no abnormalities.
• 0.35 ml/kg (=307 mg/kg): slight to severe erythema, slight edema and
• 0.7 ml/kg (=614 mg/kg): moderate to severe erythema, moderate to
severe edema and extensive hemorrhages.
• 1.4 ml/kg (=1228 mg/kg): severe erythema, moderate to severe edema,
extensive hemorrhages, apathy, sialorrhoea, dyspnea, dark discoloration
of irises, paresis and/or paralysis.
Mortality amounted to 25% at 0.35 and 0.7 ml/kg bw, and to 100% at 1.4
Growth was slightly disturbed at 0.35 and 0.7 ml/kg bw.
Food and water intake and haematology were not affected by 1,4
Microscopic examination at autopsy revealed treatment related changes in
the skin at 0.35 and 0.7 ml/kg bw.
There were no distinct differences in reactions either between rabbits
treated on the intact or abraded skin, or between male and female
DAB: LD50(rabbit, dermal):
0.7-1.4 ml/kg body weight (=614 -1228 mg/kg bw); extrapolated: 825 mg/kg
Classification DSD (400< LD50
<2000 mg/kg): Xn Harmful, R22 Harmful in contact with skin.
CLP (200 -1000 mg/kg): GHS06 Toxic (cat.3) H311 Toxic in
contact with skin
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again