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EC number: 203-782-3
CAS number: 110-60-1
A: 1:1 mixture of FCA and water for injection
B: A 0.1% test substance concentration (experimental); vehicle (control)
C: 1:1 mixture of FCA and a 0.2% concentration (experimental) or vehicle
Skin effects intradermal injections:
NA: no abnormalities
E: Erythema graded according to Draize
N: Signs of necrosis (mm in diameter)
7 Experimental animals were intradermally injected with a 0.1%
concentration and epidermally exposed to a 10% concentration, while 3
control animals were similarly treated, but with the vehicle only.
2 Weeks after the epidermal application all animals were challenged with
a 2% test substance concentration and the vehicle. The challence
reactions were assessed 24 and 48 hours after bandage removal.
No evidence was obtained that DAB (1,4 Diaminobutane) caused skin
hypersensitivity in the guinea pig. This result leads to a sensitisation
rate of 0%, indicating that DAB (1,4 Diaminobutane) need not to be
regarded as a potential skin sensitiser.
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