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EC number: 203-782-3 | CAS number: 110-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Principles of method if other than guideline:
- A series of aqueous solutions of 1,4-diaminobutane and lactic acid were prepared in the range of concentrations 2mM-100mM. Samples were taken to calibrate the analytical method (DAB by gas chromatography, LA by high performance liquid chromatography).
Next, 10ml of octanol was contacted with 10ml of a given solution in a glass bottle (volume 100ml). Bottles were placed in the shaking bath and incubated for 66h at T=25¿C and shaking speed of 185rpm. Afterwards, bottles were left for 2h in order to allow for settling of phases. Samples of aqueous phase were taken and submitted to further analysis. pH was measured and concentrations of remaining 1,4-diaminobutane and lactic acid in aqueous phase were determined Based on the measured concentrations in aqueous phase, the concentration in organic phase was calculated by mass balance principle. Obtained data was transformed into diagram where the slope of created line expresses partitioning coefficient of the solute between water and octanol. - GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Tetramethylenediamine
- EC Number:
- 203-782-3
- EC Name:
- Tetramethylenediamine
- Cas Number:
- 110-60-1
- Molecular formula:
- C4H12N2
- IUPAC Name:
- butane-1,4-diamine
Constituent 1
Study design
- Analytical method:
- gas chromatography
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -0.84
- Temp.:
- 25 °C
- pH:
- 10.45 - 11.86
- Details on results:
- For 1,4 diaminobutane the octanol/water partitioning p o/w is 0.145 ±0.05 . This is equal to logP of -0.84.
Any other information on results incl. tables
Applicant's summary and conclusion
- Conclusions:
- The log kow =-0.84
- Executive summary:
The n-octanol/water partition coëfficient (Kow) for tetramethylene diamine is 0,145. The log (Kow) is -0,84.
The kow is a critical parameter for the chemical safety assesment (CSA), the classification and labeling and the PBT assesment. For organic substances the potential for bioaccumulation shall normally be determined by using the octanol/water partition coefficient, usually reported as a log Kow. Kow = 4 is intended to identify only those substances with a real potential to bioconcentrate. Based on the log (Kow) we can conclude that tetramethylenediamine should not be identified as a real potential to bioconcentrate.
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