Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-782-3 | CAS number: 110-60-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Principles of method if other than guideline:
- A series of aqueous solutions of 1,4-diaminobutane and lactic acid were prepared in the range of concentrations 2mM-100mM. Samples were taken to calibrate the analytical method (DAB by gas chromatography, LA by high performance liquid chromatography).
Next, 10ml of octanol was contacted with 10ml of a given solution in a glass bottle (volume 100ml). Bottles were placed in the shaking bath and incubated for 66h at T=25¿C and shaking speed of 185rpm. Afterwards, bottles were left for 2h in order to allow for settling of phases. Samples of aqueous phase were taken and submitted to further analysis. pH was measured and concentrations of remaining 1,4-diaminobutane and lactic acid in aqueous phase were determined Based on the measured concentrations in aqueous phase, the concentration in organic phase was calculated by mass balance principle. Obtained data was transformed into diagram where the slope of created line expresses partitioning coefficient of the solute between water and octanol. - GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Tetramethylenediamine
- EC Number:
- 203-782-3
- EC Name:
- Tetramethylenediamine
- Cas Number:
- 110-60-1
- Molecular formula:
- C4H12N2
- IUPAC Name:
- butane-1,4-diamine
Constituent 1
Study design
- Analytical method:
- gas chromatography
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -0.84
- Temp.:
- 25 °C
- pH:
- 10.45 - 11.86
- Details on results:
- For 1,4 diaminobutane the octanol/water partitioning p o/w is 0.145 ±0.05 . This is equal to logP of -0.84.
Any other information on results incl. tables
Applicant's summary and conclusion
- Conclusions:
- The log kow =-0.84
- Executive summary:
The n-octanol/water partition coëfficient (Kow) for tetramethylene diamine is 0,145. The log (Kow) is -0,84.
The kow is a critical parameter for the chemical safety assesment (CSA), the classification and labeling and the PBT assesment. For organic substances the potential for bioaccumulation shall normally be determined by using the octanol/water partition coefficient, usually reported as a log Kow. Kow = 4 is intended to identify only those substances with a real potential to bioconcentrate. Based on the log (Kow) we can conclude that tetramethylenediamine should not be identified as a real potential to bioconcentrate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
