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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: number of animals too small

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report Date:
1960

Materials and methods

Principles of method if other than guideline:
2 ml of a 20 % solution of the test substance in methylene chloride was sprayed in a 400 l vessel in which 1 rabbit, 1 guinea pig, 2 rats and 4 mice were placed. after 1 hour the same amount was sprayed again into the vessel. after 2 hours the animals were removed from the vessel. the test was repeated on 5 consecutive days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity: >99%

Test animals

Species:
other: 1 rabbit, 1 guinea pig, 2 rats and 4 mice
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: methylene chloride
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 days
Frequency of treatment:
2 hours once a day
Doses / concentrations
Remarks:
Doses / Concentrations:
1 mg/l
Basis:
nominal conc.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no data

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Remarks on result:
not determinable
Remarks:
no NOAEC identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
all animals died within 14 days. The animals had strong mucosal irritations and showed elaborated breathing.

Applicant's summary and conclusion

Executive summary:

method: 4 ml of a 20 % solution of the test substance in methylen chloride was sprayed in a 400 l vessel in which 1 rabbit, 1 guinea pig, 2 rats and 4 mice were placed. after 1 hour the same amount was sprayed again into the vessel. after 2 hours the animals were removed from the vessel. the test was repeated on 5 consecutive days.

result. all animals died within 14 days