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EC number: 203-176-9
CAS number: 104-12-1
Erythema (score 2 of max.4) and oedema (day 1: score 2-3,
from day 2: score 3 of max.4) appeared on day 1 in all
Desquamation was observed from day 5 until the end of the
observation period (day 14).
On Day 14 erythema disappeared in one animal only, but
persisted in the 5 others (4/5: score 1, 1/5: score 2 of max
4 and desquamation). Oedema was still seen in all animals
(2/6: score 1 and 4/6: score 2 of max.4)
method: the study was conducted according to the recommendations of the
OECD guideline no 404.
result: erythema and oedema apperared on day 1 in all animals. the
reactions were very important and induced a desquamation from day 5
until the end of the observation period (day 14). on day 14, erythema
disapperared in one animal only, but persisted in the five others.
oedema was still seen in all animals. the compound was considered as
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