Registration Dossier

Administrative data

Description of key information

acute oral toxicity: LD50 = 138 mg/kg bw (rat, female); LD50 = 335 mg/kg bw (rat, male); other studies found a LD50 > 2000 mg/kg bw (rat, male); LD50 = 6000 mg/kg bw (rat, m+f) or LD50 = 4750 mg/kg bw (rat, m+f)
acute inhalation toxicity: LC50 = ca.113 mg/m³ (rat, female); LC50 = 113-272 mg/m³(rat, male)
acute dermal toxicity: LD50 > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
138 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
113 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

For the acute oral toxicity T, R25 is justified as a result of the LD50 = 138 mg/kg bw

For the acute inhalation toxicity T+, R26 is justified as a result of the LC50 = 113 mg/m³ air

In addition, several studies reported respiration irritational effects. Therefore R 37 is applicable