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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: results sufficiently stated

Data source

Reference
Reference Type:
publication
Title:
Maximum permissible concentration of p-chlorophenyl isocyanate in factory air
Author:
Frolova IN
Year:
1966
Bibliographic source:
Hygiene & Sanitation 31 (7-9), 481-483 (Engl. translation)

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
threshold of irritating effects on eyes (no further data) was determined
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
TS-Freetext:
4-Chlorophenyl isocyanate, no purity specified

Method

Subjects:
human volunteers (no further data)
Route of exposure:
ocular
Reason of exposure:
intentional
Exposure assessment:
not specified

Results and discussion

Clinical signs:
subjects complained of unpleasant sensations in their eyes

Any other information on results incl. tables

RM-Freetext:
In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure (no further
information from the English translation of the Russian

publication)

Applicant's summary and conclusion

Executive summary:

In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure.

The subjects complained of unpleasant sensations in their eyes.