4-chlorophenyl isocyanate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: In compliance with current guideline, but individual animal data were not shown

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Principles of method if other than guideline:

Method: other: see freetext ME

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-chlorophenyl isocyanate

EC Number:

203-176-9

EC Name:

4-chlorophenyl isocyanate

Cas Number:

104-12-1

Molecular formula:

C7H4ClNO

IUPAC Name:

1-chloro-4-isocyanatobenzene

Details on test material:

IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, no data on purity

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

2

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

no symptoms or deaths occured over a 14-day observation period

Clinical signs:

other: no symptoms or deaths occured over a 14-day observation period

Gross pathology:

at the time of sacrifice, a gross necropsy revealed a darkened ring at the base of the cortex of the kidneys.
other internal organs appeared normal

Other findings:

no data

Any other information on results incl. tables

RS-Freetext:
No symptoms or death occurred during the 14-day observation
period.
Gross necropsy revealed a darkened ring at the base of the
cortex of the kidneys; other internal organs appeared
normal.

Applicant's summary and conclusion

Executive summary:

method:

Backs of 2 males and 2 females were shaved and abraded by scrubbing. 

Compound was applied undiluted to the skin at a dose level of 2000 mg/kg. Animals were observed 14 days for symptoms and mortality.
Gross necropsy was performed with a general inspection of
the digestive tract, liver, kidneys, heart lungs and spleen.

result: No symptoms or death occured during the 14-day observation period.