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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: In compliance with current guideline, but individual animal data were not shown

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Principles of method if other than guideline:
Method: other: see freetext ME
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, no data on purity

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
2
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
no symptoms or deaths occured over a 14-day observation period
Clinical signs:
no symptoms or deaths occured over a 14-day observation period
Body weight:
no data
Gross pathology:
at the time of sacrifice, a gross necropsy revealed a darkened ring at the base of the cortex of the kidneys.
other internal organs appeared normal
Other findings:
no data

Any other information on results incl. tables

RS-Freetext:
No symptoms or death occurred during the 14-day observation
period.
Gross necropsy revealed a darkened ring at the base of the
cortex of the kidneys; other internal organs appeared
normal.

Applicant's summary and conclusion

Executive summary:

method:

Backs of 2 males and 2 females were shaved and abraded by scrubbing. 

Compound was applied undiluted to the skin at a dose level of 2000 mg/kg. Animals were observed 14 days for symptoms and mortality.
Gross necropsy was performed with a general inspection of
the digestive tract, liver, kidneys, heart lungs and spleen.

result: No symptoms or death occured during the 14-day observation period.