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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only one dose applied

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report Date:
1960

Materials and methods

Principles of method if other than guideline:
Method: other: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1 % solution in oil (no further data)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
14 working days
Frequency of treatment:
once per day
Doses / concentrations
Remarks:
Doses / Concentrations:
100 mg/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Post-exposure period: ca. 4 weeks

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
100 mg/kg bw/day (nominal)
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no recognizable effects

Applicant's summary and conclusion

Executive summary:

method: oral application of 100 mg/kg of an oily solution (1%) to rats on 14 consecutive working days

result: no recognizable effects