Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-176-9 | CAS number: 104-12-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documentation - no standard method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- other: single intraperitoneal application, 1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw (no further data) - GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity: >99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: oil (not further specified)
- Doses:
- 100, 75, 62.5, 50, 25, 10 mg/kg bw
- No. of animals per sex per dose:
- 1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw;
3 rats/group 25 and 10 mg/kg bw - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 62.5 mg/kg bw
- Mortality:
- see remarks on results
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
RS-Freetext:
100 mg/kg bw: mortality: 1/1
75 mg/kg bw: mortality: 5/5
62.5 mg/kg bw: mortality: 2/5
50 mg/kg bw: mortality: 1/5
25 mg/kg bw: mortality: 0/3
all animals displayed signs of intoxication increasing with
increasing of dose including decreased motility, rough fur,
staggering gait
10 mg/kg bw was tolerated without any finding
Applicant's summary and conclusion
- Executive summary:
method: single intraperitoneal application in mice. 1 rat received 100 mg/kg bw; 5 rats/group 75, 62.5 and
50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw
result: LD50 (rat,ip) = ca. 62.5 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
