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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documentation - no standard method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Principles of method if other than guideline:
other: single intraperitoneal application, 1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw (no further data)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorophenyl isocyanate
EC Number:
203-176-9
EC Name:
4-chlorophenyl isocyanate
Cas Number:
104-12-1
Molecular formula:
C7H4ClNO
IUPAC Name:
1-chloro-4-isocyanatobenzene
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity: >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: oil (not further specified)
Doses:
100, 75, 62.5, 50, 25, 10 mg/kg bw
No. of animals per sex per dose:
1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw;
3 rats/group 25 and 10 mg/kg bw
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
62.5 mg/kg bw
Mortality:
see remarks on results
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

RS-Freetext:
100   mg/kg bw: mortality: 1/1
 75   mg/kg bw: mortality: 5/5
 62.5 mg/kg bw: mortality: 2/5
 50   mg/kg bw: mortality: 1/5
 25   mg/kg bw: mortality: 0/3
all animals displayed signs of intoxication increasing with
increasing of dose including decreased motility, rough fur,
staggering gait
10 mg/kg bw was tolerated without any finding

Applicant's summary and conclusion

Executive summary:

method: single intraperitoneal application in mice. 1 rat received 100 mg/kg bw; 5 rats/group 75, 62.5 and

50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw

result: LD50 (rat,ip) = ca. 62.5 mg/kg bw