Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documentation - no standard method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report Date:
1960

Materials and methods

Principles of method if other than guideline:
other: single intraperitoneal application, 1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw (no further data)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity: >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: oil (not further specified)
Doses:
100, 75, 62.5, 50, 25, 10 mg/kg bw
No. of animals per sex per dose:
1 rat received 100 mg/kg bw;
5 rats/group 75, 62.5 and 50 mg/kg bw;
3 rats/group 25 and 10 mg/kg bw
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
62.5 mg/kg bw
Mortality:
see remarks on results
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

RS-Freetext:
100   mg/kg bw: mortality: 1/1
 75   mg/kg bw: mortality: 5/5
 62.5 mg/kg bw: mortality: 2/5
 50   mg/kg bw: mortality: 1/5
 25   mg/kg bw: mortality: 0/3
all animals displayed signs of intoxication increasing with
increasing of dose including decreased motility, rough fur,
staggering gait
10 mg/kg bw was tolerated without any finding

Applicant's summary and conclusion

Executive summary:

method: single intraperitoneal application in mice. 1 rat received 100 mg/kg bw; 5 rats/group 75, 62.5 and

50 mg/kg bw; 3 rats/group 25 and 10 mg/kg bw

result: LD50 (rat,ip) = ca. 62.5 mg/kg bw