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EC number: 200-309-2 | CAS number: 57-06-7
The main effects observed in short-term toxicity studies in rats and mice, dosed by gavage, were a thickened mucosal surface of the stomach, adhesion of the stomach to the peritoneum and a thickened urinary bladder wall (the latter change being mainly observed in the males of both species). This indicates that AITC has irritant effects on these tissues. The No-Observed-Adverse-Effect-Levels (NOAELs) from short-term and subchronic toxicity studies in rats and mice which received AITC by gavage were in the range of 10 to 25 mg/kg bw/day. The NOAELs identified in subchronic toxicity studies were mainly based on the effects on kidney, stomach and urinary bladder observed at higher doses.
AITC is not classified for Specific Target Organ Toxicity, according to Regulation (EC) n. 1272/2008.
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