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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1993
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Reference:
Composition 0
Principles of method if other than guideline:
Allyl Isothiocyanate displays excellent solubility in ethanol.
0.5 ml each of a mixture of Allyl Isothiocyanate and ethanol were mixed thoroughly in sealed bottles and stored for two weeks at 4, 28 or 40°C.
Allyl Isothiocyanate content was measured by Gas Chromatography after one day and again after two weeks of storage.
The sample stored at 4°C was kept in storage until the sixth month, when its composition was analyzed by GC/MS.
GLP compliance:
not specified
Test material information:
Composition 1
Specific details on test material used for the study:
Allyl Isothiocyanate purity: 99.9%
Test substance stable:
no
Transformation products:
yes
No.:
#1
Reference substance:
Composition 1

In the presence of ethanol, Allyl Isothiocyanate decomposed more rapidly. When stored at 40°C, about 15% decomposed in 2 weeks. Even at 4°C, measurement by GC/MS showed that ethyl allyl thiocarbamate had formed over 26% of the surface area after 6 months of storage

 

Stability of Allyl Isothiocyanate in ethanol:

 

Residual level (%)

Storage temperature

Initial

1 day

2 weeks

4°C

100

100

99.3

28°C

100

99.3

91.1

37°C

100

97.6

78.0

 

Conclusions:
In the presence of ethanol, Allyl Isothiocyanate produced an additional compound (ethyl allyl thiocarbamate), therefore a mixture of teh test item with ethanol is not feasible as basis for a pratical preparation of Allyl Isothiocyanate.

Description of key information

In the presence of ethanol, Allyl Isothiocyanate produced an additional compound (ethyl allyl thiocarbamate).

Additional information