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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Acute and Long-Term Effects of Nine Chemicals on the Japanese Medaka (Oryzias latipes)
Author:
G.W.Holcombe, D.A.Benoit, D.E.Hammermeister, E.N.Leonard, R.D.Johnson
Year:
1995
Bibliographic source:
Arch. Environ. Contam. Toxicol. 28, 287-297 (1995)

Materials and methods

Principles of method if other than guideline:
96-hours acute test was conducted with nine organic chemicals, usng the Japanese medaka (Oryzias latipes) as the test organism.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Oryzias latipes

Study design

Test type:
not specified
Water media type:
other: Lake Superior water
Total exposure duration:
96 h

Test conditions

Hardness:
The mean and range for total hardness was 45.8 (38.0-52.0) mg/L as CaCO3 for all tests.
Test temperature:
25 C +/- 1
pH:
7.88 +/- 0.18

Results and discussion

Effect concentrations
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.077 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The 96-hours LC50 (Oryzias latipes) value for allyl isothiocyanate was 0.077 mg/L.