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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

Type of composition:
legal entity composition of the substance
State / form:
solid: particulate/powder
Related composition:
L-histidine SIEF
Reference substance:
PBT status:
the substance is not PBT / vPvB

L-histidine was determined to be rapidly biodegradable based on the result of the study of Mueller and Neumann (1981) showing 50% degradation after 5 days.

Bioaccumulation of L-histidine can be excluded based on its low log Kow of -3.32

L-histidine is not classified as carcinogenic, mutagenic, toxic for reproduction or Specific Target Organ Toxicity after repeated exposure according to Regulation EC No. 1272/2008 (CLP). L-histidine was determined not to be aquatic toxic based on the NOEC values in daphnia (>= 100 mg/L) and algae (10 mg/L).