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An acute toxicity test to Daphia test was performed according to OECD 202, as a limit test at test concentration 100 mg/L. L-Histidine was found not to be toxic to Daphnia magna. The EC50 value is > 100 mg/L and NOEC ≥100 mg/L.

The toxicity to algae was investigated in a study according to OECD 201. Algae were exposed for 72h to 5 test concentrations 4.6, 10, 22, 46 and 100 mg/L. The EC50 values were > 100 mg/L and 74 mg/L for growth rate and yield respectively. The EC10 values found were 58 mg/L for growth rate and 31 mg/L for yield.

According to Guidance document Chapter R.7b, section R.7.8 short-term toxicity tests to fish do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur. Nevertheless, the short-term toxicity to fish was calculated by EpiSuite's EcoSAR model. ECOSAR estimates the 96h LC50 for fish to be 375000 mg/L. This is far above water solubility so mortalities greater than 50% would not occur in a saturated solution during an exposure period of 96 hours.

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