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EC number: 200-745-3 | CAS number: 71-00-1
Effect of amino acids on spontaneous mutagenesis in E. coli
Values are the means of relative mutants per total cells data (mutant frequency on test plates divided by mutant frequency on control plates) from triplicate plate-assay experiments for LacZ53 strains.
Amino acid tested
Relative Lac+mutagenesis in the presence of 2 mM
Values did not indicate a significant effect on mutagenesis by either of two criteria.
In this study, 19 amino acids were tested to see if their catabolism was mutagenic, using uvrB cells. More specifically, the goal was to find a type of mutagenesis that is regulated by DNA repair genes. The study was not GLP and no OECD guideline was followed. A plate assay for mutagenesis was performed in which E. coli strains were incubated with the test substance for 3 days at 37°C with or without glucose present. Hereafter, Lac+ mutants were scored and the ratio test/control was determined, taking into account the growth-normalization factors.
L-histidine did not show a significant effect on Lac reversion in the uvrB strain, and thus, was found not to be mutagenic.
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