Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed handbood

Data source

Reference
Reference Type:
review article or handbook
Title:
Patty´s Industrial Hygiene and Toxicology
Author:
Hine, Rowe, White, Darmer, Jr. and Youngblood
Year:
1981
Bibliographic source:
3rd ED. 1981 Vol II A, page 2237- 2240

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
This information does not come from a test report and the minimum fields can not be filled in.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 380 mg/kg bw

Applicant's summary and conclusion

Conclusions:
No information is available concerning methods used, guidelines followed. However, as the data comes from a peer-reviewed handbook, the information is connsidered to be of the high quality (reliability Klimisch 2). The test material did induce mortality in rats when administered intraperitoneally. An LD50 of >380 mg/kg is given.
Executive summary:

The Patty´s Industial Hygiene and Toxicology also contains information about 1,2,3 -propanetriol, glycidyl ethers (Patty's Industial Hygiene and Toxicology, 3erd Ed, Hine et al., 1981). There is mentionned, that the substance, when adminstered intraperitoneally to rats, an LD50 value of >380 mg/kg bw is given.