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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer-reviewed handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Handbook of Filler, Extenders, and Diluents
Author:
Ash, I.
Year:
2007
Bibliographic source:
Edition 2, P76, Synapse Info Resources 2007.

Materials and methods

Principles of method if other than guideline:
As this information comes from a peer-reviewed handbook, no information is available on i.e. the methods and on the guidelines followed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of 2-(chloromethyl)oxirane and glycerol
EC Number:
701-197-2
Molecular formula:
6 individual glycidether components (Molecular range ca. 200 - 600 g/mol)
IUPAC Name:
Reaction products of 2-(chloromethyl)oxirane and glycerol

Test animals / tissue source

Species:
other: not given

Results and discussion

In vivo

Results
Irritation parameter:
other: effects on eyes
Reversibility:
other: possible risks of irreversible effects
Remarks on result:
other: strongly irritating to eyes and skin
Irritant / corrosive response data:
strongly irritating to eyes and skin, possible risks of irreversible effects

Applicant's summary and conclusion

Interpretation of results:
other: Category 2 (irritating) based on EU GHS criteria
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
No information is available concerning animals or methods used, guidelines followed. However, as the information comes from a peer-reviewed handbook, the information is considered to be of the high quality (reliability Klimisch 2). For the test material it is stated that the substance is strongly irritating to eyes and skin, with possible risks of irreversible effects. The test material does require classification, according to regulation (EC) 1272/2008.
Executive summary:

The Handbook of Filler, Extenders, and Diluents also gives some information about the eye irritating potential of 1,2,3 -propanetriol, glycidyl ethers (Handbook of Filler, Extenders, and Diluents, Ash, 2.nd Edition, 2007). There is stated that the substance is strongly irritating to eyes and skin, with possible risks of irreversible effects. No further details are given.