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Registration Dossier
Diss Factsheets
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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented publication, which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Epoxy Resins
- Author:
- Hine, C.H., Kodama, J.K., Anderson, H.H., Simonson, D.W., Wellington, J.S.
- Year:
- 1 958
- Bibliographic source:
- AMA archive s of industrial health / American Medical Association, 17, p. 129-144
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The irritating effect of the test material was tested on normal rabbit eyes by dropping 0.1 mL of a 20% suspension in propylene glycol on the center of the cornea. Readings were made at 1, 24 and 48 hours, with the cornea unstained and then stained with a 2% solution of fluorescein sodium. Injury was scored according to the method of Draize.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- IUPAC Name:
- Polyglycidyl Ether of Substituted Glycerin (EPON 562)
- Details on test material:
- - Name of test material (as cited in study report): EPON 562
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 - 3.2 kg
Test system
- Vehicle:
- other: propylene glycol
- Controls:
- other: yes the other eye served as control
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 48 hours
- Number of animals or in vitro replicates:
- no details given
- Details on study design:
- Dropping 0.1 mL of a 20 % suspension in propylene glycol on the centre of the cornea
SCORING SYSTEM: according to Draize
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24 and 48 hours
- Score:
- 82
- Max. score:
- 120
- Reversibility:
- not specified
- Remarks on result:
- other: severely irritating
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This well-documented publication gives a detailed information about the experiments conducted and meets basic scientific principles. Therefore it is considered to be of the high quality (reliability Klimisch 2). The validity criteria of the test system are fulfilled. EPON 562 was severely irritating to rabbit eyes (score 82 of 120).
- Executive summary:
The eye irritation potential of EPON 562 was investigated by Hine et al.(Hine, 1958). The irritating effect was tested on normal rabbit (male Albino) eyes by dropping 0.1 mL of a 20% suspension in propylene glycol on the center of the cornea. Readings were made at 1, 24, and 48 hours, with the corneas unstained and then stained with a 2% solution of fluorescein sodium. Injury was scored according to the method of Draize. EPON 562 was severely irritating to rabbit eyes (score 82 of maximum 120).
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