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EC number: 701-197-2
CAS number: -
In order to assess the toxicological behaviour of 1,2,3-propanetriol, glycidyl ethers, the available physico-chemical and toxicological data have been evaluated. The substance is expected to be well absorbed after oral exposure, based on its water solubility, its logPow of -1.78 / -1.94 and acute toxicity data via oral administration. Concerning the absorption after exposure via inhalation, as the chemical has low vapour pressure and is highly hydrophilic, it is clear, that the substance is poorly available for inhalation and will not be absorbed significantly.1,2,3-propanetriol, glycidyl ethersis also not expected to be absorbed following dermal exposure into the stratum corneum and into the epidermis, due to its molecular weight and its logPow. Concerning its distribution in the body1,2,3-propanetriol, glycidyl ethersis expected to be distributed mainly in the intravasal compartment, due to its logPow. The substance does not indicate a significant potential for accumulation.1,2,3-propanetriol, glycidyl ethersis expected to be metabolised mainly via epoxide hydrolases (esterases), cytochrome P450s and alcohol dehydrogenase and subsequently eliminated unchanged or as metabolites via the urine.
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