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Short-term toxicity to fish

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Description of key information

Calculation with ECOSAR v0.99g (EPIWIN software by US-EPA): 
- Main component with chlorine: LC50(96h): 57.09 mg/L;
- Main component without chlorine: LC50(96h): 55.17 mg/L;
Prediction by read-across (the OECD QSAR Toolbox, v.3.3., 2014):
- Main component with chlorine: EC50(96h): 72.4 mg/L;
- Main component without chlorine: LC50(96h): 79.3 mg/L.

Key value for chemical safety assessment

Additional information

The acute toxicity to fish of the test substance was predicted by the computer program ECOSAR v0.99g (EPIWIN software) by US-EPA (Chemservice S.A., 2012; prediction performed by data owner). An extensive set of structure – activity relationships (SARs) is utilized by the computer program, to predict the acute and chronic toxicity for three trophic levels for aquatic species, based on the neutral organics SAR (Baseline Toxicity).The mode of toxic action for most neutral organic chemicals is narcosis, and many chemical classes present toxicity to organisms via narcosis (i.e. ethers, alcohols, ketones). However, some organic chemical classes have been identified as having a more specific mode of toxicity. These are typically organics that are reactive and ionizable and that exhibit excess toxicity in addition to narcosis (i.e. acrylates, epoxides, anilines). For the test substance,“diepoxides” were detected as Ecosar-class.The short-term results (LC50) for the substance including chlorine concerning fish (96h) was given as 57.09 mg/L. Additionally, a LC50 of 13.17 mg/L is given after an exposure time of 14 days. If the compound contains no chlorine, the predicted results differ a little; the LC50(96h) is 55.17 mg/L and after 14 days exposure to fish, the LC50 is predicted as 12.08 mg/L.Therefore, it can be assumed that the toxicity is not significantly affected by a chlorine molecule.

Similarly, there is no big difference in the predicted EC50 and LC50 values for chemical structures of GE 100 either with or without chlorine component using read-across of the OECD QSAR Toolbox (v.3.3., 2014).

GE 100 was assigned as "Epoxides" by the general categorization method "US EPA New Chemical Categories". In both cases with and without chlorine component, chemicals with the same profiling result and for which experimental data are available have been retrieved from the database. Then, the chemicals containing other chemical elements and/or organic functional groups in their structures have been considered to be dissimilar to the target chemical and were removed from the domain. According to ECOSAR – a hazard estimation tool developed by EPA, epoxides represent hazard to the aquatic environment if their molecular weight is lower than 1000 g/mol and logPow < 5 (EPA, 2010). Common properties of epoxides, which could be relevant for acute aquatic toxicity endpoint, are high reactivity to biomolecules and cytotoxicity. Therefore, the chemicals with different to GE-100 protein binding mechanism have been eliminated from the domain as well. The chemicals used for read-across possess an identical to GE 100 glycidyloxy moiety in their structures. An acute aquatic EC50 of 72.4 and LC50 of 79.3 mg/L for fish is predicted for GE-100 without and with chlorine component, respectively.