Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-197-2 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Calculation with ECOSAR v0.99g (EPIWIN software by US-EPA):
Main component with chlorine: EC50(48h): 4.38 mg/L
Main component without chlorine: EC50(48h): 4.06 mg/L
Key value for chemical safety assessment
Additional information
The acute toxicity to Daphnia magna of the test substance was predicted by the computer program ECOSAR v0.99g (EPIWIN software) by US-EPA (Chemservice S.A., 2012; prediction performed by data owner).An extensive set of structure – activity relationships (SARs) is utilized by the computer program, to predict the acute and chronic toxicity for three trophic levels for aquatic species, based on the neutral organics SAR (Baseline Toxicity).The mode of toxic action for most neutral organic chemicals is narcosis, and many chemical classes present toxicity to organisms via narcosis (i.e. ethers, alcohols, ketones). However, some organic chemical classes have been identified as having a more specific mode of toxicity. These are typically organics that are reactive and ionizable and that exhibit excess toxicity in addition to narcosis (i.e. acrylates, epoxides, anilines). For the test substance,“diepoxides” were detected as Ecosar-class.The short-term results (EC50) for the substance including chlorine concerning daphnids (48h) was given as 4.38 mg/L. If the compound contains no chlorine, the predicted result differ a little; the EC50(48h) is 4.06 mg/L. Therefore, it can be assumed that the toxicity is not significantly affected by a chlorine molecule.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
