Registration Dossier

Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study accepted by U.S. authorities and WHO.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Influence of high levels of minerals on the susceptibility of chicks to Salmonella gallinarum
Author:
Hill CH
Year:
1974
Bibliographic source:
Journal of Nutrition 104(10):1221–1226
Reference Type:
secondary source
Title:
CICAD 69, Cobalt and inorganic cobalt compounds
Author:
WHO
Year:
2006
Reference Type:
secondary source
Title:
Ecological soil screening levels for Cobalt
Author:
U.S. EPA
Year:
2005
Bibliographic source:
Washington, DC, United States Environmental Protection Agency, Office of Solid Waste and Emergency Response, 57 pp. (OSWER Directive 9285.7-67; http://www.epa.gov/ecotox/ecossl/pdf/eco-ssl_cobalt.pdf).

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Analytical purity: no data
Dose method:
feed
Analytical monitoring:
no
Vehicle:
no

Test organisms

Test organisms (species):
other: Gallus domesticus

Study design

Limit test:
no
Total exposure duration (if not bolus):
14 d
Nominal and measured doses / concentrations:
0, 50, 100, 200, 300, 400 ppm Co

Results and discussion

Effect levelsopen allclose all
Duration (if not bolus):
14 d
Dose descriptor:
NOEL
Effect level:
50 mg/kg diet
Conc. / dose based on:
element
Remarks:
Co
Basis for effect:
body weight
Duration (if not bolus):
14 d
Dose descriptor:
LOEL
Effect level:
100 mg/kg diet
Conc. / dose based on:
element
Remarks:
Co
Basis for effect:
body weight

Applicant's summary and conclusion