Cobalt di(acetate)

Long-term toxicity to fish

Administrative data

Endpoint:

fish, juvenile growth test

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Acceptable, well documented study which meets basic scientific principles. Test performance similar to OECD 215, however lethality and teratogenesis were observed. Exposure concentrations of elements were confirmed by AAS. Since results were based on both teratogenesis and lethality of embryo-larval stages, the determined LC1 as given in this publications may be used as a NOLC. This is underlined by the fact, that a good correlation between LC1 and MATC´s of the various metals were observed.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Aquatic toxicity tests on inorganic elements occuring in oil shale.

Author:

Birge WJ et al.

Year:

1980

Bibliographic source:

In: Gale C, ed. Oil shale symposium. Sampling, analysis and quality assurance. Cincinnati, OH, United States Environmental Protection Agency, pp. 519–534 (EPA-600/9-80-022; NTIS PB80 221435).

Reference 2

Reference Type:

secondary source

Title:

CICAD 69, Cobalt and inorganic cobalt compounds

Author:

WHO

Year:

2006

Materials and methods

Principles of method if other than guideline:

static renewal (12hr)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cobalt dinitrate

EC Number:

233-402-1

EC Name:

Cobalt dinitrate

Cas Number:

10141-05-6

IUPAC Name:

cobalt(2+) dinitrate

Details on test material:

- Name of test material (as cited in study report): Co(NO3)2, "hydratet", no further data
- Analytical purity: no data

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

other: static renewal (12hr)

Water media type:

freshwater

Limit test:

no

Total exposure duration:

28 d

Test conditions

Hardness:

92-100 mg/L CaCO3

Test temperature:

12-13°C

pH:

6.9-7.8

Dissolved oxygen:

9.3-10.1 mg/L

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

28 d

Dose descriptor:

other: NOLC

Effect conc.:

0.038 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

element

Remarks:

Co

Basis for effect:

other: lethality, teratogenesis

Any other information on results incl. tables

LC1 (28d) = 0.038 mg cobalt/ L

LC10 (28d) = 0.1 mg cobalt/L

LC50 (28d) = 0.49 mg cobalt/L

Control populations, maintained simultaneously with experimentals, survived at frequencies ranging from 83% to 96%.

"The LC1 for cobalt was 38.2 µg/L, and this was in reasonable agreement with an MATC of 48.7 to 112.5 µg/L, which we estimated from results on growth and survival obtained in 30-day tests with embryos and larvae of the fathead minnow. In the latter investigation, the bioconcentration of cobalt was significant at 48.7 µg/L ."