Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions. No analytical dose verification.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Effects of various metals on survival, growth, reproduction, and metabolism of Daphnia magna
Author:
Biesinger KE, Christensen GM
Year:
1972
Bibliographic source:
J Fish Res Board Can 29(12): 1691-1700
Reference Type:
secondary source
Title:
Cobalt and inorganic cobalt compounds
Author:
WHO
Year:
2006
Bibliographic source:
CICAD 69

Materials and methods

Principles of method if other than guideline:
Method: Chronic test (reproduction)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Analytical purity: reagent grade

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna
Details on test organisms:
TEST ORGANISM
- Common name: Water flea
- Source: laboratory clone, originally obtained from the University of Michigan
- Age at study initiation (mean and range, SD): 12±12h
- Feeding during test: yes

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d

Test conditions

Hardness:
appr. 45 mg/l (total)
Test temperature:
18±1°C
pH:
7.74±0.3
Dissolved oxygen:
approx. 9 mg/L

Results and discussion

Effect concentrations
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.005 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Co
Basis for effect:
other: reproduction

Any other information on results incl. tables

LC50 = 0.021 mg/l Co 
Reproductive impairment 50% = 0.012 mg/l Co
Reproductive impairment 16%= 0.01 mg/l Co

The NOEC was calculated according to TGD Part 2 (2003)
LOEC > 10 and < 20% effect: NOEC = LOEC/2.

Applicant's summary and conclusion