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EC number: 200-755-8 | CAS number: 71-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of cobalt compounds on Drosophila.
- Author:
- Tripathy NK, Patnaik RC, Panigrahi SK, Kalra S
- Year:
- 2 006
- Bibliographic source:
- J Ecobiol 18(3): 287-295
Materials and methods
- Principles of method if other than guideline:
- Eggs from wild type Oregon R flies were collected for 8 h. Second and 3rd instar larvae were collected and treated with 5ml of the desired concentrations of test compounds used for rehydration of 1.5 g of instant food. Concurrent control experiments were also run where the same age larvae were exposed to the solvent alone for similar duration. The male flies developed from these larvae were individually mated to 3 Basc females for 3 days and the resulting Oregon R/Basc F1 females were mated with their Basc/Y sibs at a ratio of 1:1 in individual vials. After 3-4 days the F2 cultures were screened for the presence of wild type males. The absence of males with wild type eyes in at least 20 flies (males and females taken together) in the F2 cultures indicated the induction of sex-linked recessive lethals.
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- 6147-53-1
- EC Number:
- 612-153-6
- Cas Number:
- 6147-53-1
- IUPAC Name:
- 6147-53-1
- Details on test material:
- - Source: manufactured by Central Drug house, New Delphi
- Name of test material (as cited in study report): cobalt acetate
- Molecular formula (if other than submission substance): Co(CH3CO2)2 4H2O
- Molecular weight (if other than submission substance): 249.1 g/mol
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Oregon R
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 2nd and 3rd instar larvae
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25±1°C
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- - Vehicle(s)/solvent(s) used: no data
- Concentration of test material in vehicle: 1.0, 2.5, 5.0 mM - Details on exposure:
- DIET PREPARATION
- Mixing appropriate amounts with (Type of food): 1.5 g of instant food from Carolina Biological Supply Co., Burlington Nc, USA, rehydrated with the different concentrations of the test compound dissolved in 5 ml of the solvent - Duration of treatment / exposure:
- 48 and 72 hours
- Frequency of treatment:
- continuously
- Post exposure period:
- none
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.0, 2.5, 5.0 mM
Basis:
nominal in diet
- No. of animals per sex per dose:
- At least 20 flies (males and females together) of F2 generation
- Control animals:
- yes, concurrent vehicle
Examinations
- Tissues and cell types examined:
- phenotype of eyes
- Evaluation criteria:
- Absence of males with wild type eyes in at least 20 flies (males and females together) in the F2 cultures.
- Statistics:
- following Kastenbaum and Bowman (1970)
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
The experiments to test the genotoxicity of the test substance in the male germ line cells were repeated, and since the lethal frequencies did not differ significantly in the two experiments, the data were pooled. Following larval exposures to different concentrations of cobalt acetate, the frequencies of induction of recessive lethals were positive only at 2.5 mM concentration.
Since they were induced only at 2.5 mM and not at 5.0 mM concentration of cobalt acetate, it indicates that the larvae must have escaped the food supplemented with the high dose of the compound since it could be repellent.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
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