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EC number: 201-177-9
CAS number: 79-10-7
Factors Which Might Have Affected the Reliability of the Results of The
Quality and External Appearance of the Test Liquid
temperature at all test concentrations was 25.1-25.9°C, and the water
temperature in one vessel in the control each day during the test period
was 25.2-25.9°C, which was within 25±2°C. The range of variation in
water temperature between vessels and between days was maintained within
±1.5°C during the period of exposure. The dissolved oxygen concentration
was 7.1-8.6 mg/L; throughout the period of exposure the dissolved oxygen
concentration was ≥60% of the saturated concentration. The pH was
6.9-7.4. As far as the external appearance of the test liquid was
concerned, no suspended solids, floating solids or precipitation were
observed during the period of exposure at any test concentration, and
the liquid was colorless. The total hardness was 46-48 mg CaCO3/L
on starting exposure and 36-42 mg CaCO3/L at the end of the
exposure, and the salt concentration was 0% both at the beginning and at
the end of exposure.
Substance Concentration in the Test Liquid
mean values for concentrations 1-5 were 0.616, 1.26, 2.47, 4.95 and 10.1
mg/L respectively. During the test period, the measured value as a
percentage of the set concentration was 89-109%, maintained within ±20%
of the set concentration during the period of exposure.
rate, First Hatching Day, Number Hatching Per Day and Final Hatching Day
hatching rate in the controls was 93.8%, satisfying the hatching rate
criterion for validity (>80%). The mean hatching rates at concentrations
1-5 were 98.8, 97.5, 100, 96.3 and 98.8%, respectively; no significant
difference was observed compared to the controls.
hatching day in the controls was day 8. The first hatching day at
concentrations 1-5 was day 7-9, 7-8, 7-8, 7-9 and 7-8, respectively; no
significant difference was observed compared to the controls.
hatching day in the controls was day 16-20. The final hatching day at
concentrations 1-5 was day 20-21, 12-23, 21, 18-21 and 10-21,
respectively; no significant difference was observed compared to the
Abnormalities in Eggs and Embryos
developmental abnormality was observed in controls and concentrations 1,
3 and 5. Retarded development was observed in one individual at
concentration 2; while at concentration 4, retarded development was
observed in one individual and inactivity in two individuals.
rate after hatching and theoverall
survival rate during the exposure periodare
shown in Table 9. The survival rate of larval and juvenile fish after
hatching is shown in Figure 3. The mean survival rate after hatching in
controls was 92.3%, which satisfied the criterion for the validity of
the study (survival rate after hatching in controls >80%). The mean
survival rates after hatching at concentrations 1-5 were 96.3, 93.6,
95.0, 94.9 and 93.7%, respectively; no significant difference was
observed compared to controls.The
mean overall survival rate during the overall exposure periodin
the controls was 86.3%, and at concentrations 1-5 the mean
overall survival rates were 95.0,
91.3, 95.0, 91.3 and 92.5% respectively.
Larval and Juvenile Fishand
larval or juvenile fish were observed through to the end of exposure in
the controls and concentrations 1-4. At concentration 5, a maximum of
two wavy fish were observed from day 10 after starting exposure, and one
wavy fish was observed at the end of exposure. Inability to swim was
observed in one fish on days 35 and 38.
As far asfeeding
status was concerned, no lowering of feeding ability was observed at any
Weight at the End of Exposure
body weight of the controls at the end of the exposure was 0.0687-0.0949
g. The average body weights at concentrations 1-5 were 0.0553-0.0806,
0.0640-0.0931, 0.0651-0.0854, 0.0906-0.0997 and 0.0781‑0.0977 g,
respectively. The average body weights at the end of exposure at
concentrations 4 and 5 were heavier than the average body weight of the
controls, with the differencebeingstatistically
significant. It was judged from this that the test substance does not
inhibit the growth of medaka, and has no lethal or sublethal effect.
Body Length at the End of Exposure
average full body length in the controls at the end of exposure was
17.78-19.36 mm. The average full body lengths at concentrations 1-5 were
16.06-18.38, 17.35-19.28, 17.06-19.15, 19.12-19.73 and 18.49-19.67 mm.
No significant difference was observed at concentrations 1-5 compared to
Acrylic acid did not cause adverse effects
in a toxicity study according to OECD TG 210.
NOEC (hatching rate, survival rate,
first/final hatching day, abnormal individuals, body weight/length; 45d,
flow-through) >= 10.1 mg/L measured (highest test concentration)
Acrylic acid was tested in a chronic
toxicity test with Oryzias latipes under flow-through conditions. The
study was conducted according to OECD TG 210 under consideration of GLP.
Based on mean measured concentrations, the 45d NOEC (for all endpoints)
was >= 10.1 mg/L. No effects could be recorded (LSI, 2019).
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