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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF-Test:Preparations of the test substance in 0.9% sodium chloride were injected into the peritoneal cavity of the mice. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Acrylic acid
EC Number:
201-177-9
EC Name:
Acrylic acid
Cas Number:
79-10-7
Molecular formula:
C3H4O2
IUPAC Name:
acrylic acid

Test animals

Species:
mouse
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: Sodium chloride (0.9%)
Doses:
20, 79, 126, 204, 250, 316, 501, 794, 1260, and 5010 mg/kg bw
No. of animals per sex per dose:
2 - 5 per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 140 mg/kg bw
Clinical signs:
Convulsions and cramps were observed after intraperitoneal injection.
Gross pathology:
Corrosions occured at the peritoneum parietale and peritoneum viscerale.

Any other information on results incl. tables

Table 1: Results

Mortality

Dead/Treated

Dose (mg/kg bw)

24 h

48 h

7 d

20

0/2

0/2

0/2

79

0/2

0/2

0/2

126

0/5

1/5

2/5

204

0/5

1/5

5/5

250

1/5

3/5

5/5

316

3/3

3/3

3/3

501

5/5

5/5

5/5

794

5/5

5/5

5/5

1260

2/2

2/2

2/2

5010

2/2

2/2

2/2

Applicant's summary and conclusion