Registration Dossier
Registration Dossier
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EC number: 201-177-9 | CAS number: 79-10-7
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study of DNA adduct formation in vivo
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- carcinogenicity
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- prop-2-enoic acid
- Details on test material:
- Acrylic acid was 2,3-14C labelled. No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.1 M Na2HPO4
- Details on exposure:
- 130 µL [2,3-14CJacrylic acid was dissolved in 1.9 mL 0.1 M Na2HP04 and the pH was adjusted about 5.5 with 0.2 mL 27% NaOH.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- single
- Post exposure period:
- 24 h
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
233/ 257 mg/kg bw
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
7.9-8.7*10e9 dpm/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 2
- Control animals:
- yes, concurrent vehicle
Results and discussion
- Details on results:
- No DNA adducts were detectable neither in the liver nor in the stomach.
Any other information on results incl. tables
Based on the limit of detection, a maximum possible DNA binding of AA will be at least 100,000 times below the DNA binding potency of the standard carcinogen aflatoxin B1.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
