Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-177-9 | CAS number: 79-10-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Modified Maguire Method
- GLP compliance:
- no
- Type of study:
- split adjuvant test
- Justification for non-LLNA method:
- A reliable in vivo test was available before the implementation of the OECD 429 method.
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- Molecular formula:
- C3H4O2
- IUPAC Name:
- prop-2-enoic acid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Acrylic acid
- Analytical purity: no data
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- Induction: 0.1 mL aliquot of the test substance
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- no data
- Concentration / amount:
- not specified
- No. of animals per dose:
- 10
- Details on study design:
- - Positive control:
For induction, 10 guinea pigs were routinely subjected to the same dosing regimen with the diglycidyl ether of 2,2-di-(p,p'-hydroxyphenyl)propane (DER* 331 Epoxy Resin -- Dow Chemical U .S .A .), a known sensitizer to serve as a positive control . Challenge was performed two weeks after the last injection of the induction series. - Positive control substance(s):
- yes
- Remarks:
- 2,2-Di-(p,p'-hydroxyphenyl)propane didlycidyl ether (DER* 331 Epoxy Resin -- Dow Chemical U .S .A .)
Results and discussion
- Positive control results:
- The positive reference substance ( DER* 331 Epoxy Resin) induced moderate skin sensitization.
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 mL
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- positive control
- Dose level:
- no data
- No. with + reactions:
- 7
- Total no. in group:
- 10
- Group:
- negative control
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Preliminary study:
Prior to conducting the sensitization test, the test material was applied as received to the clipped flanks of animals to determine if primary irritation would occur. If significant irritation was observed, dilutions of the test material were made in a suitable solvent. The highest concentration which did not cause primary irritation was used for the sensitization test.
Test group:
Substance |
animals tested |
animals sensitized |
Acrylic acid (0.1 mL aliquot) |
10 |
0 |
Sensitization with the test substance was not observed in this test.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
