Hexafluorosilicic acid

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-standard investigation; published study

Data source

Reference

Reference Type:

publication

Title:

Histological findings in the skin of animals after percutaneous damage by hydrofluoric and hexafluorosilicic acid

Author:

Alhassan A & Zink P

Year:

1982

Bibliographic source:

Zeitschrift fur Rechtsmedizin 88(4):239-47

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Non-standard invetsigation of the histology of hexafluorosilic acid burns in rats, guinea pigs and pigs

GLP compliance:

no

Remarks:

: punlished study

Test material

Test material information

Constituent 1

Reference substance name:

Hexafluorosilicic acid

EC Number:

241-034-8

EC Name:

Hexafluorosilicic acid

Cas Number:

16961-83-4

Molecular formula:

F6Si.2H

IUPAC Name:

Dihydrogen hexafluorosilicate

Details on test material:

Hexafluorosilicic acid (concentrated) and hydrofluoric acid

Test animals

Species:

other: rat, guinea-pig, pig

Strain:

not specified

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

water

Controls:

not required

Duration of treatment / exposure:

No data

Observation period:

No data

Number of animals:

No data

Results and discussion

In vivo

Results

Irritation parameter:

other: Histological examination

Basis:

other: Guinea-pigs

Time point:

other: 1h, 3-6h, 1-2 weeks

Score:

1

Max. score:

1

Reversibility:

not reversible

Remarks on result:

other: hypocellular necrosis and edema reaching as far as the subcutis

Other effects:

Necrosis and oedema; not scored according to standard criteria.

Any other information on results incl. tables

The intact skin was not generally affected by the acids. Areas injured before application of the acid showed, however, a continuous spreading of necrosis in the deeper regions. The first histological changes were noticed 1 hour after the application and were seen long before any macroscopic reaction. The main characteristic findings were the hypocellular necrosis and oedema reaching as far as the subcutis. The necrosis showed sharp leukocyte demarcations.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The findings of this non-standard investigative study are consistent with the current 'Corrosive' classification of the substance.

Executive summary:

In a non-standard investigative study, the morphological changes in the skin of animals were studied after application of concentrated hydrofluoric and hexafluorosilicic acid. The intact skin was not generally affected by the acids. Areas injured before application of the acid showed, however, a continuous spreading of necrosis in the deeper regions. The first histological changes were noticed 1 hour after the application and were seen long before any macroscopic reaction. The main characteristic findings were the hypocellular necrosis and oedema reaching as far as the subcutis. The necrosis showed sharp leukocyte demarcations. The findings of this non-standard investigative study are consistent with the current 'Corrosive' classification of the substance.