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Diss Factsheets
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EC number: 241-034-8 | CAS number: 16961-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read across justification
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 32 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 66.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Fluoride
- Basis for effect:
- growth rate
- Key result
- Duration:
- 32 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 83.9 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- weight
- Remarks on result:
- other: Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range corresponds to 83.9 mg hexafluorosilicic acid/L.
- Remarks:
- Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range corresponds to 83.9 mg hexafluorosilicic acid/L.
- Details on results:
- - Mortality/survival at embryo, larval, juvenile, and adult stages:control and up to nominal 150 mg/L > 80% in each replicate. no mortality in any of the test solutions up to 150 mg/L.
- Days to hatch: 4.5
- Numbers hatched: tpyically > 80 %, 100% in all test solutions.
- Number of healthy fish at end of test: 90% in control, 100% in test solutions up to 150 mg/L, 18 % at nominal 300 mg/L
- Effect concentrations exceeding solubility of substance in test medium: none
- Incidents in the course of the test which might have influenced the results: none
Applying the conversion factor from F- to hexafluorosilicic acid, the concentration range corresponds to 83.9 mg hexafluorosilicic acid/L. - Reported statistics and error estimates:
- Dunnetts test
- Validity criteria fulfilled:
- yes
- Conclusions:
- 32d-NOEC 66.6 mg F-/L (applied as NaF, measured F- concentration), this NOEC corresponds to 83.9 mg hexafluorosilicic acid/L.
- Executive summary:
In an ELS study similar to OECD 210, the 32d-NOEC was determined to be 66.6 mg F-/L (applied as NaF, measured F- concentration). The study is considered to be reliable with restrictions (no GLP statement). All relevant raw data were reported. This information has been reviewed by the US-EPA (D. Bush, 2007) and been considered in general relevant for the risk assessment of fluorides.
Applying the conversion factor from F- to hexafluorosilicic acid, the NOEC corresponds to 83.9 mg hexafluorosilicic acid/L.
In accordance with the US-EPA (D. Bush, 2007) this study is considered relevant for the risk assessment of fluorides and hence also hexafluorosilicic acid.
Reference
Description of key information
32d-NOEC: 83.9 mg hexafluorosilicic acid/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 83.9 mg/L
Additional information
In the key ELS study similar to OECD 210, the 32d-NOEC was determined to be 66.6 mg F-/L (applied as NaF, measured F- concentration). The study is considered to be reliable with restrictions (no GLP statement; Klimisch 2). All relevant raw data were reported. This information has been reviewed by the US-EPA (D. Bush, 2007) and been considered in general relevant for the risk assessment of fluorides. Applying the conversion factor from F- to hexafluorosilicic acid, the NOEC corresponds to 83.9 mg hexafluorosilicic acid/L. In accordance with the US-EPA (D. Bush, 2007) this study is considered relevant for the risk assessment of fluorides and hence also hexafluorosilicic acid.
In a disregarded Klimisch 3 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg F-/L was reported (actual concentration). In the original publication this value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water. Applying the conversion factor from F- to hexafluorosilicic acid, the concentration corresponds to 5.04 mg hexafluorsilicic acid/L. Due to methodological differences to modern test guidelines for long-term toxicity testing for fish, this study is disregarded and considered as not relevant for the risk assessment of hexafluorosilicic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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