Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-034-8
CAS number: 16961-83-4
On the first day of exposure the test article concentrations were below
target, therefore the exposure period was extended for 1 hour.
The overall mean concentration values recorded for the 91 day exposure
period were 0, 0.12, 0.88 and 9.21 ppm for the 0, 0.1, 1.0 and 10 ppm
concentration levels, respectively.
Chamber uniformity measurements were completed during pre-validation and
the first week of animal exposures, and found to be acceptable.
The potential toxicity of hydrogen fluoride (HF) gas was determined in
Fischer 344 rats. Twenty rats per sex were exposed to HF gas at
concentrations of 0 (filtered-air only), 0.1, 1.0 and 10 ppm, for 6
hours/day, 5 days/week for 13 weeks.
Six rats (5 males and 1 female) from the high dose group died during the
study. There were marked body weight decreases in rats exposed to 10
ppm, accompanied by some decreases in selected absolute organ weight
values. Clinical signs of toxicity were limited to the animals exposed
to 10 ppm, and included red ocular discharge and rough coats. Some
effects on haematology and clinical chemistry parameters were detected,
but the changes were slight and considered to be of minimal
toxicological significance. The authors concluded that dental
malocclusions noted at necropsy were likely to be a contributing factor
to changes in blood values and body weights.
It was concluded that repeated exposure of rats to 10 ppm HF caused
non-specific progressive toxicity, characterised by general malaise and
loss of body weight. The authors also mentioned a decreased appetite and
decreased food consumption, although there were no data reported to
support this. The toxic effects of HF appeared to be more severe in
The NOAEL can be considered to be 0.88 ppm (analytical), equivalent to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again