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EC number: 241-034-8 | CAS number: 16961-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Workers were exposed to a variety of compounds, including hexafluorosilicic acid, hydrogen fluoride and silicon tetraluoride. Paper summarised in NTP review (seondary source).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Risk of fluorosis in the manufacture of phosphate fertilizers
- Author:
- Fabbri L , De Rosa E, Potenza I, Mapp C, Rossi A, Brighenti F & Forin F
- Bibliographic source:
- La Medicina del lavoro 69(5) 594-604
- Reference Type:
- secondary source
- Title:
- Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature
- Author:
- Haneke KE & Carson BL
- Year:
- 2 001
- Bibliographic source:
- National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709 Contract No. N01-ES-65402
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Epidemiological study investigating the risk of fluorosis in workers involved in the manufacture of phosphate fertiliser.
- GLP compliance:
- no
- Remarks:
- : not applicable
Test material
- Reference substance name:
- Hexafluorosilicic acid
- EC Number:
- 241-034-8
- EC Name:
- Hexafluorosilicic acid
- Cas Number:
- 16961-83-4
- Molecular formula:
- F6Si.2H
- IUPAC Name:
- Dihydrogen hexafluorosilicate
- Details on test material:
- Workers were exposed to gaseous fluoride (hydrogen fluoride, silicon tetrafluoride, and hexafluorosilicic acid).
Constituent 1
Method
- Details on study design:
- 50 workers were engaged for approximately 30 years in the production of phosphate fertilisers.
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Nine of 50 workers had increased bone densities. Urinary fluoride excretion ranged from 1.0 to 9.6 mg/L
- Confounding factors:
- Workers were co-exposed to gaseous fluoride (hydrogen fluoride, silicon tetrafluoride, and hexafluorosilicic acid), therefore no effects can be attributed to hexafluorosilicic acid.
- Strengths and weaknesses:
- Workers were co-exposed to gaseous fluoride (hydrogen fluoride, silicon tetrafluoride, and hexafluorosilicic acid), therefore no effects can be attributed to hexafluorosilicic acid.
Any other information on results incl. tables
Increased bone density and increased urinary excretion of fluoride were reported, however workers were also exposed to hydrogen fluoride and silicon tetrafluoride in addition ro hexafluorosilicic acid. No conclusion can therefore be reached regarding the contribution of hexafluorosilicic acid.
Applicant's summary and conclusion
- Conclusions:
- Increased bone density and increased urinary excretion of fluoride were reported, however workers were also exposed to hydrogen fluoride and silicon tetrafluoride in addition to hexafluorosilicic acid. No conclusion can therefore be reached regarding the contribution of hexafluorosilicic acid.
- Executive summary:
The risk of fluorosis in workers involved in the manufacture of phosphate fertiliser was investigated in 50 workers engaged for approximately 30 years. Urine levels of fluoride were measured and bone density assessed. Increased bone density and increased urinary excretion of fluoride were reported, however workers were also exposed to hydrogen fluoride and silicon tetrafluoride in addition ro hexafluorosilicic acid. No conclusion can therefore be reached regarding the contribution of hexafluorosilicic acid.
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