Registration Dossier
Registration Dossier
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EC number: 241-034-8 | CAS number: 16961-83-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read across justification
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 126.552 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- NaF
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other:
- Remarks:
- test started 23 June 1987
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3 199.99 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- NaF
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other:
- Remarks:
- test started 23 June 1987
- Details on results:
- Applying the conversion factor from NaF to hexafluorosilicic acid, the EC10 and EC50 for respiration inhibition corresponds to 642.4 and 1824 mg hexafluorosilicic acid/L.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC10 and EC50 for respiration inhibition corresponds to 642.4 and 1824 mg hexafluorosilicic acid/L.
- Executive summary:
In an OECD 209 study (repiration inhibition), the EC10 and EC50 were determined to be 1127 and 3200 mg NaF/L.
Applying the conversion factor from NaF to hexafluorosilicic acid, the EC10 and EC50 for respiration inhibition corresponds to 642.4 and 1824 mg hexafluorosilicic acid/L.
Reference
Description of key information
EC10 and EC50 for respiration inhibition corresponds to 642.4 and 1824 mg hexafluorosilicic acid/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 824 mg/L
- EC10 or NOEC for microorganisms:
- 624.4 mg/L
Additional information
From an OECD 209 study from Bayer (1987) it can be concluded that theEC10 and EC50 for respiration inhibition corresponds to 642.4 and 1824 mg hexafluorosilicic acid/L.
The EU RAR reports NOEC values of between 7.1 -231 mg F-/L for various test designs. The NOEC of 231 mg F-/L was reported for a 16 h Pseudomonas putida test (Brinkmann and Kühn,1977). Applying the conversion factor from F- to hexafluorosilicic acid, the concentration for the Pseudomonas putida test corresponds to 291 mg hexafluorosilicic acid/L.
Based on the study from Ochoa-Herrera et al. (2009), there is evidence that sewage treatment plant microorganisms can adapt within short time to concentrations of > 500 mg F-/L. This result supprts the finding from the Bayer study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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