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Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result:

THEIC is considered to behave quasi-inert in live organisms. This is consistent with the absence of any relevant adverse effects in all in vitro and in vivo toxicity studies and ecotoxicology tests performed with THEIC,and with its hydrolytic stability. However, THEIC has no bioaccumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

After oral uptake, THEIC is expected to be readily absorbed in the gastro-intestinal tract and to become systemically available, because of its high water solubility, moderately low molecular weight and hydrolytic stability.

 

After inhalation exposure, absorption and systemic availability of the rather small inhalable fraction of THEIC is expected to be 100%, because of its high water solubility.

 

Dermal absorption of THEIC is considered to be low. In view of its high water solubility and low n-octanol/water partition coefficient, THEIC is considered to be too hydrophilic to cross the lipid rich environment of the stratum corneum.

 

THEIC is considered to behave quasi-inert in live organisms. This is consistent with the absence of any adverse effects in all in vitro and in vivo toxicity studies and ecotoxicology tests performed with THEIC, and with its hydrolytic stability. However, THEIC does not have a bioaccumulation potential. Quasi-inert behaviour of another structurally similar substance is reported for cyanuric acid or 1,3,5-triazinetrione (EC No. 203-618-0, CAS No. 108-80-5). Based on the similarities of these two substances read-across of toxicological data is proposed. The results of toxicokinetic studies performed with 14C labelled cyanuric acid in rats, dogs and human volunteers demonstrating rapid excretion of un -metabolised cyanuric acid via urine and/or faeces can be considered as supporting evidence for the quasi -inert behaviour of THEIC.