Registration Dossier
Registration Dossier
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EC number: 212-660-9 | CAS number: 839-90-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
- Remarks:
- (as given in OECD SIDS)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Test organisms (species):
- Oryzias latipes
- Test type:
- semi-static
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC10
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
- Measured concentrations (as mg/L): <0.9 for control, 91.9 for the test solution at the beginning of the test; <0.9 for control, 92.0 for the test solution after 24 h
- Abnormal response: No abnormal responses in the test solution and control during exposure
- Reference substance result: LC50 of copper sulfate pentahydrate at 96 h; 1.5 mg/L.
Nominal concentrations (as mg/L): 0 and 100
Measured concentrations (as mg/L): 91.9(Day 0)-92.0(Day 1)
Unit [results expressed in what unit]: % survival after 24, 48, 72, 96 h
Element value: 96h-LC50 is above 100 mg/L based on nominal concentration
Statistical results: binomial
- Biological observations: No abnormal response at the test
concentration and control during the exposure.
- Table showing cumulative mortality
_____________________________________________________
Nominal Measured Cumulative mortality
Concentration Concentration (%)
(mg/L) (mg/L) 24h 48h 72h 96h
Control <0.9 0 0 0 0
100 91.9-92.0 0 0 10 10- Conclusions:
- 96h-LC50 of tris(2-hydroxyethyl) isocyanurate was greater than 100 mg/L and 96h-LC10 of that was 100 mg/L.
Reference
Description of key information
LC50 (96h) >100 mg/L for Oryzias latipes (OECD TG 203)
Key value for chemical safety assessment
Additional information
Value used for CSA:LC50 for freshwater fish: > 100 mg/L
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