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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: according to information in OECD SIDS (2002)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Identity: Tris(2-hydroxyethyl) isocyanurate (CAS: 839-90-7)
- Source: Nissan Chemical Industries Ltd.; Lot No. 00915-1
- Purity: 99.0 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
- Age of the animals at study initiation: 5 weeks old

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
for injection
Doses:
0, 500, 1,000, 2,000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
yes
Details on study design:
Control animals comprised a concurrent vehicle control group
Statistics:
Not applicable, because of no fatality. 

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
None
Clinical signs:
No treatment related clinical sign observed.
Body weight:
No compound-related effect was observed. Body weight changes in treated groups were similar to that of the control.
Gross pathology:
No treatment-related abnormalities.
Other findings:
There was no treatment-related adverse effect.

Applicant's summary and conclusion

Interpretation of results:
other: LD50 > 2000 mg/kg body weight
Conclusions:
There were no treatment related abnormalities. LD50 is greater than 2,000 mg/kg for both sexes.