Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-859-9 | CAS number: 100-51-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reporting suffers from deficiencies
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The classification of Skin irritants by human patch test
- Author:
- Basketer DA, Chamberlain M, Griffiths HA, Rowson M, Shittle E, York M
- Year:
- 1 997
- Bibliographic source:
- Food Chem Toxicol 35, 845-852
- Reference Type:
- publication
- Title:
- Determination of skin irritation potential in the human 4-h patch test
- Author:
- Basketer DA, York M, McFadden JP, Robinson MK
- Year:
- 2 004
- Bibliographic source:
- Contact Dermatitis 51, 1-4
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- patch test in humans
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Details on test material:
- no further data
Constituent 1
Method
- Type of population:
- general
- Subjects:
- volunteers
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- patch test in human
- Examinations:
- skin irritancy
- Medical treatment:
- no data
Results and discussion
- Clinical signs:
- 1/31 weekly positive reaction usually characterized by mild erythema or dryness across most of the treatment site)
compared to 17/32 in the positive control group - Results of examinations:
- weekly positive reaction(usually characterized by mild erythema or dryness across most of the treatment site) was observed in 1/31 volunteers compared to 17/32 in the positive control group. Therefore it was concluded that there is no need to classify
- Effectivity of medical treatment:
- no data
- Outcome of incidence:
- 1/31 (mild erythema) vs 17/32 in the positive control group
Any other information on results incl. tables
weekly positive reaction(usually characterized by mild erythema or dryness across most of the treatment site) was observed in 1/31 volunteers compared to 17/32 in the positive control group Therefore it was concluded that there is no need to classify
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
