Benzyl alcohol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Reliability score 2 on the basis of the weight of evidence found during review of public documents existing relating to toxicological data

Data source

Reference

Reference Type:

review article or handbook

Title:

Benzyl Alcohol

Author:

NPIRI (National Assoc. of Printing Ink Research Institute)

Year:

1974

Bibliographic source:

Raw Material Data Handbook, Vol.1:( Organic Solvents), 6,1974.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OTS 798.1100 (Acute Dermal Toxicity)

Principles of method if other than guideline:

The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl alcohol

EC Number:

202-859-9

EC Name:

Benzyl alcohol

Cas Number:

100-51-6

Molecular formula:

C7H8O

IUPAC Name:

phenylmethanol

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

4 male/female rabbits

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw.

No. of animals per sex per dose:

4 male/female rabbits

Control animals:

yes

Details on study design:

The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no signs of systemic or organ toxicity were noted.

Clinical signs:

other: no signs of systemic or organ toxicity were noted.

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Conclusions:

The compound exhibit low acute toxicity for the dermal route the LD50 values are > 2000mg/kg bw. Data published in the NPIRI: Raw Mater. Data Handb. Vol. 1, 6 (1974) report show that after acute dermal application is > 2000 mg/kg bw to the intact and abraded skin of rabbits for 24 hours under occlusive conditions, no signs of systemic or organ toxicity were noted. On this basis dermal classification of benzyl alcohol deemed to be non-toxic.