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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Reliability score 2 on the basis of the weight of evidence found during review of public documents existing relating to toxicological data

Data source

Reference
Reference Type:
review article or handbook
Title:
Benzyl Alcohol
Author:
NPIRI (National Assoc. of Printing Ink Research Institute)
Year:
1974
Bibliographic source:
Raw Material Data Handbook, Vol.1:( Organic Solvents), 6,1974.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EPA OTS 798.1100 (Acute Dermal Toxicity)
Principles of method if other than guideline:
The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
4 male/female rabbits

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw.
No. of animals per sex per dose:
4 male/female rabbits
Control animals:
yes
Details on study design:
The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no signs of systemic or organ toxicity were noted.
Clinical signs:
no signs of systemic or organ toxicity were noted.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The compound exhibit low acute toxicity for the dermal route the LD50 values are > 2000mg/kg bw. Data published in the NPIRI: Raw Mater. Data Handb. Vol. 1, 6 (1974) report show that after acute dermal application is > 2000 mg/kg bw to the intact and abraded skin of rabbits for 24 hours under occlusive conditions, no signs of systemic or organ toxicity were noted. On this basis dermal classification of benzyl alcohol deemed to be non-toxic.