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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
other: reviewed data on dermal absorption
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: reviewed data on dermal absorption

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Benzylalcohol
Author:
DFG (Deutsche Forschungsgemeinschaft/German Research Foundation)
Year:
2006
Bibliographic source:
MAK value documentation on benzyl alcohol; The MAK Collection for Occupational Health and Safety, Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb10051d0040/pdf; only available in German)
Reference Type:
publication
Title:
In vivo percoutaneous absorption of fragance ingredientts in rhesus monkeys and humans
Author:
Bronaugh RL, Wester RC, Bucks D, Maibach HI, Sarason R cited in DFG 2006
Year:
1990
Bibliographic source:
Fd Chem Toxicol 28,369-373

Materials and methods

Principles of method if other than guideline:
acccording to the method of Wester and Maibach(1975) Toxicol Appl Pharmacol 32, 394-398
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
purity 97 %
Radiolabelling:
yes

Test animals

Species:
monkey
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: occlusive and open
Vehicle:
acetone
Duration of exposure:
24 hours
Doses:
4 µg/cm²
No. of animals per group:
no data
Control animals:
no
Remarks:
no data

Results and discussion

Percutaneous absorptionopen allclose all
Dose:
of the applied dose
Parameter:
percentage
Absorption:
ca. 32 %
Remarks on result:
other: in 24 h
Remarks:
unoccluded conditions 
Dose:
applied dose
Parameter:
percentage
Absorption:
ca. 56 - <= 80 %
Remarks on result:
other: in 24 h
Remarks:
Absorption through occluded skin was high (56-80 %) in 24 h.
Conversion factor human vs. animal skin:
no data

Any other information on results incl. tables

RM-Freetext: Benzyl alcohol as a fragrance ingredient used in cosmetic and other products is lipophilic and therefore has the potential to be readily absorbed through skin. The percutaneous absorption was determined in vivo in rhesus monkeys. Absorption through occluded skin was high (56-80 %) in 24 h. No correlation was seen between skin penetration and the octanol-water partition coefficient. Under unoccluded conditions skin penetration was reduced (32 %), because of evaporation of the compound.

Applicant's summary and conclusion