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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable and sufficiently documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
10 male rats received a single oral application per gavage of 1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml/kg bw (= ca. 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw) of the test substance. Post-exposure period was 14 days.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl alcohol
EC Number:
202-859-9
EC Name:
Benzyl alcohol
Cas Number:
100-51-6
Molecular formula:
C7H8O
IUPAC Name:
phenylmethanol
Details on test material:
- Name of test material (as cited in study report): Benzylalkohol
no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
male Wistar rats, SPF, weight 160 - 180 g; husbandry: 5 animals per cage; breeder: Winkelmann

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
single oral application per gavage (no further data)
Doses:
1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml/kg bw (= ca. 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw)
No. of animals per sex per dose:
10 male rats per dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: start and end of study
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight
Statistics:
LD50 according Fink and Hund, Arzneimittelforschung (1965), 15, 624

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1.55 mL/kg bw
95% CL:
1.42 - 1.7
Remarks on result:
other: corresponding to 1620 mg/kg bw (density: 1.045 g/mL)
Sex:
male
Dose descriptor:
other: NOAEL
Effect level:
1 mL/kg bw
Remarks on result:
other: corresponding to 1045 mg/kg bw
Mortality:
dose 1.0 ml/kg bw, mortality 0/10; dose 1.2 ml/kg bw, mortality 1/10; dose 1.4 ml/kg bw, mortality 2/10; dose 1.5 ml/kg bw, mortality 6/10; dose 2.0 ml/kg bw, mortality 8/10; dose 2.1 ml/kg bw, mortality 10/10;
Clinical signs:
other: 1.0 ml/kg bw: no clinical findings from 1.2 ml/kg bw onwards: sedation, side and prone-position, bloody eyes and reduction of general condition
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

10 male rats received a single oral application per gavage of 1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml benzyl alcohol/kg bw (= 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw; density: 1.045 g/ml) and were observed for 14 days. Clinical signs were observed from 1.2 ml/kg bw onwards and included sedation, side and prone position, bloody eyes and reduction of general condition. The resulting LD50 was 1.55 ml/kg bw (= 1620 mg/kg bw) (Bayer AG 1978).