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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Hemolysis of erythrocytes by anitbacterial preservatives
Author:
Ansel HC, Cadwallader DE.:
Year:
1964
Bibliographic source:
J. Pharm. Sci. 53, 169-172
Reference Type:
other: abstract
Title:
Hemolytic effect of benzyl alcohol
Author:
McOrmond P, Gulck B, Duggan HE, Hopper J
Year:
1980
Bibliographic source:
Drug Intell. Clin. Pharm. 14, 549

Materials and methods

Type of study / information:
in vitro
Principles of method if other than guideline:
fresh blood from rabbits and healthy donors were incubalted with the testsubstance in vitro in the presence of 0.9 % MaCl
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no further data

Results and discussion

Any other information on results incl. tables

RM-Freetext:
Benzyl alcohol can cause hemolysis of human and rabbit
erythrocytes in the presence of 0.9 % NaCl.

Applicant's summary and conclusion