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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
long-term toxicity to fish, other
Remarks:
(Q)SAR calculated endpoint
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
The substance is readily biodegradable and considered to be of low risk to fish.

Data source

Reference
Reference Type:
other: QSAR model
Title:
EPI Suite v 4.0/ECOSAR v1.00
Author:
US EPA
Year:
2014
Bibliographic source:
http://epa.gov/oppt/exposure/pubs/episuite.htm

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
ECOSAR Program (v1.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
not required

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
other: Fish species
Details on test organisms:
no further information

Study design

Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
30 d

Test conditions

Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
SMILES : OCc(cccc1)c1
CHEM : Benzenemethanol
CAS Num: 100-51-6
MOL FOR: C7 H8 O1
MOL WT : 108.14
Log Kow: 1.08 (KowWin estimate)
Wat Sol: 4.29E+004 mg/L (experimental database)
Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
48.897 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: (Q)SAR prediction
Remarks on result:
other: non-toxic , as determined by (Q)SAR
Details on results:
A NOEC value of 48.897 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .

Any other information on results incl. tables

Overview of QSARs estimations onlong-term aquatic toxicity of  benzyl alcohol to fish

 

Method

 

Results

Remarks

Reference

QSAR

estimate

Fish, 96-hr LC50 =504.664 mg/L (ppm)

Fish 30-day ChV = 48.897 mg/L (ppm)

 

Reliable with restrictions,

QSAR estimated data

ECOSAR Program (v1.00)

 

 

Fish, 96-hr LC50 =504.664mg/L (ppm)

Fish 30-day ChV =48.897mg/L (ppm)

 

 

 

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
A NOEC value of 48.897 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
Executive summary:

The ECOSAR QSAR model predicts that the NOEC for freshwater fish would to be 48.897 mg/l .This result signifies that the test substance is not expected to be toxic .