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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Ocular tolerance of preservatives on the murine cornea
Author:
Furrer P, Mayer JM, Plazonnet B, Gurny R
Year:
1999
Bibliographic source:
Europ J Pharmaceutics, Biopharmaceutics 47, 105-112

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
instilling testsubstance on the murine cornea (3 days) and determing the microlesions on the conrnea
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
analytical grade

Test animals

Species:
mouse
Strain:
NMRI
Sex:
not specified

Administration / exposure

Route of administration:
other: dropps on the cornea
Vehicle:
water
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 days
Frequency of treatment:
4 times per day, 2.5 hours apart
Post exposure period:
no
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 %
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Details on results:
0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days
resulted in a 10 % damage of the corneal surface

Any other information on results incl. tables

0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days resulted in a 10 % damage of the corneal surface

Applicant's summary and conclusion