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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Ocular tolerance of preservatives on the murine cornea
Author:
Furrer P, Mayer JM, Plazonnet B, Gurny R
Year:
1999
Bibliographic source:
Europ J Pharmaceutics, Biopharmaceutics 47, 105-112

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
instilling testsubstance on the murine cornea (3 days) and determing the microlesions on the conrnea
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl alcohol
EC Number:
202-859-9
EC Name:
Benzyl alcohol
Cas Number:
100-51-6
Molecular formula:
C7H8O
IUPAC Name:
phenylmethanol
Details on test material:
analytical grade

Test animals

Species:
mouse
Strain:
NMRI
Sex:
not specified

Administration / exposure

Route of administration:
other: dropps on the cornea
Vehicle:
water
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 days
Frequency of treatment:
4 times per day, 2.5 hours apart
Post exposure period:
no
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 %
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Details on results:
0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days
resulted in a 10 % damage of the corneal surface

Any other information on results incl. tables

0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days resulted in a 10 % damage of the corneal surface

Applicant's summary and conclusion