Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: While the study documentation may be regarded as sufficient (short report) the statistical evaluation is less reliable due to low number of animals.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1967

Materials and methods

Principles of method if other than guideline:
other: "standard"
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: Isophorone diisocyanate submitted by P.G. Naylor, Division Chemicals and Plastics Research and Development, South Charleston, W.Va. (USA); sponsor's ID 38-MPW-105 / 29-DS-10-5; internal ID 30-182

Test animals

Species:
rat
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: no vehicle
Doses:
106; 212; 423; 846 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
222 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
MORTALITY: 
- Number of deaths at each dose: 
  0.8 ml/kg: 5/5 within less than 1 day
  0.4 ml/kg: 3/5 within 1 day
  0.2 ml/kg: 4/5 within 1 day
  0.1 ml/kg: 0/5
CLINICAL SIGNS: slight tremors, heavy breathing
NECROPSY FINDINGS: congestion throughout the lungs and the abdominal  viscera
LD50 = 0.21 (0.13-0.35) ml/kg = 222 (138-370) mg/kg

Applicant's summary and conclusion