Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Releases into the environment are efficiently prevented by technical and organizational measures during production of isophorone diisocyanate, formulation and use of formulations as well as from its use as a monomer for the production of polymers or other downstream products. Releases into the environment may occur accidentally or during professional applications of low concentrated products.


Distribution modelling according to Mackay Level I indicates that the main target compartments will be soil and sediment with approximately 43 % each, followed by water with about 10 %.The calculated Henry’s law constant of 0.941 Pa m3/mol (vapor pressure x molecular weight / water solubility) at 20-23 °C indicates low volatility from aqueous solution. Both Henry’s law constant and adsorption / desorption constant cannot be studied due to rapid hydrolysis of isophorone diisocyanate. Environmental distribution considerations for isophorone diisocyanate are of little relevance because the reaction with water is expected to eliminate the substance from the environment rapidly.

The rate constant of the OH radical sensitized indirect photodegradation of isophorone diisocyanate corresponds to a half-life of 1.8 days at a 24 hour mean OH radical concentration of 500,000 molecule/cm³, which is typical of Central Europe. A preliminary hydrolysis test resulted in a dissipation half-life of 0.84 hours (approx. 50 minutes) at 23 °C. No ready biodegradation (0% degradation within 28 days) was observed in a manometric respiratory test performed with domestic, non-adapted activated sludge according to Directive 92/69/EEC, C.4-D. Biodegradation of the substance itself is irrelevant as primary degradation step because hydrolysis is much faster.

Rapid hydrolysis of the substance makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation.