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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
other:
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Isophorondiisocyanat / Chemikalien und Kontaktallergie - Eine bewertende Zusammenstellung
Author:
Kayser D and Schlede E (Eds.)
Year:
2001
Bibliographic source:
Urban & Vogel Medien und Medizin Verlagsgesellschaft mbH & Co. KG., München 17+2 pp

Materials and methods

Study type:
human medical data
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
data collection, published as a loose-leaf-book

Method

Type of population:
occupational
Ethical approval:
not applicable
Details on study design:
expert judgement on the potency ranking of chemicals with contact allergenic properties

Results and discussion

Results:
Based on experience in humans and animals the substance is ranked as a category B sensitiser. There are indications of cross-reactivity with other diisocyanates. Diisocyanates are known to cause inhalation allergies (Deutsche Forschungsgemeinschaft, 1995).

Applicant's summary and conclusion

Conclusions:
The test item was ranked as a Category B sensitizer.
Executive summary:

The test item was ranked as a Category B sensitizer. Substances with a solid-based indication of a contact allergenic potential and substances with the capacity of cross reactions were listed in Category B. 

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