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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

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Administrative data

health surveillance data
Type of information:
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference Type:
Isophorondiisocyanat / Chemikalien und Kontaktallergie - Eine bewertende Zusammenstellung
Kayser D and Schlede E (Eds.)
Bibliographic source:
Urban & Vogel Medien und Medizin Verlagsgesellschaft mbH & Co. KG., München 17+2 pp

Materials and methods

Study type:
human medical data
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
data collection, published as a loose-leaf-book


Type of population:
Ethical approval:
not applicable
Details on study design:
expert judgement on the potency ranking of chemicals with contact allergenic properties

Results and discussion

Based on experience in humans and animals the substance is ranked as a category B sensitiser. There are indications of cross-reactivity with other diisocyanates. Diisocyanates are known to cause inhalation allergies (Deutsche Forschungsgemeinschaft, 1995).

Applicant's summary and conclusion

The test item was ranked as a Category B sensitizer.
Executive summary:

The test item was ranked as a Category B sensitizer. Substances with a solid-based indication of a contact allergenic potential and substances with the capacity of cross reactions were listed in Category B.