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3 -Isocyanatomethyl-3,5,5 -trimethylcyclohexyl isocyanate hydrolyses upon contact with water. The diisocyanate groups of the substance react by forming amines (i.e. 3-aminomethyl-3,5,5-trimethylcyclohexylamine) and CO2. The amines formed may react further with unreacted diisocyanate groups of 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate resulting in oligo- and subsequently polyurea components.

Test substance solutions of 3 -isocyanatomethyl-3,5,5 -trimethylcyclohexyl isocyanate were prepared at nominal concentrations that were some orders of magnitude higher than the maximum water solubility. The solutions were stirred for 18 to 24 hours and insoluble particles were filtered off. Substance concentrations were determined as DOC/TOC and were back-calculated to the parent compound.

The lowest toxicity values were derived for the aquatic invertebrates Daphnia magna and Chaetogammarus marinus. The EC50 was 27 mg/L for Daphnia magna (parent substance) and 4.0 mg/L for Chaetogammarus marinus.