Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Allergic contact dermatitis from N-(cyclohexlthio)phthalimide in a playground fitter
Author:
Loffeld A and Foulds IS
Year:
2004
Bibliographic source:
Contact Dermatitis 51, 212-213

Materials and methods

Study type:
clinical case study

Test material

Constituent 1
Chemical structure
Reference substance name:
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate
EC Number:
223-861-6
EC Name:
3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate
Cas Number:
4098-71-9
Molecular formula:
C12H18N2O2
IUPAC Name:
5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Positve reactions were observed on days 2 and 4 with
- cyclohexylthiophthalimide (1 % pet.)
- isophoronediisocyanate (no details reported).
He subsequently avoided contact with the rubber material and his symptoms  have cleared.

Applicant's summary and conclusion